About one in every 400 black infants is born with the condition. Eight to 10% of the US black population possesses the trait (Behrman and Vaughan 1987). A person with this life-long disease has an With this change in a crisis in the patient with the sickle cell trait (Smith and Gelbman 1986). SCD results from any combination of the sickle cell gene with any other abnormal β-globin gene and there are many types of SCD. Diagnosis of Sickle Cell Anemia Aside from clinical manifestations of SCA, labora-tory data must be documented to … This guideline covers managing acute painful sickle cell episodes in children, young people and adults who present at hospital, from presentation until when they are discharged. The management of acute and chronic pain for individuals living with sickle cell disease (SCD) is a clinical challenge. Sickle cell disease is a term used for a group of conditions in which the pathology is due to the presence of hemoglobin S. Sickle cell anemia, or homozygous sickle cell disease, results from the inheritance of a sickle cell gene from both parents. the most severe form of SCD and is commonly called sickle cell anemia.7 HbSC is a form of SCD inherited when a child receives one sickle gene (“S”) from one parent and abnormal hemoglobin, known as “C” gene, from the other parent. It aims to reduce variation in how acute episodes are managed in hospital, focusing on … The most common types include sickle cell anemia (Hb SS), the sickle beta-thalassemias (Hb Sβ0 and Hb Sβ+), hemoglobin SC disease (Hb SC) and sickle cell disease with hereditary persistence of fetal hemoglobin (S/HPFH). Sickle Cell Anemia Fact Sheet Sickle Cell Anemia Sickle cell anemia is a recessive genetic blood disorder caused by a defect in the gene which codes for hemoglobin. The defective gene is called hemoglobin S, which changes the shape of the red blood cells from circular to crescent- or sickle-shaped. Other genotypes of sickle cell disease result Sickle Cell Anemia: A Parent’s Guide for the Infant and Young Child Important Facts about Sickle Cell Anemia (Hb SS) Sickle cell anemia is the most common serious genetic disease in Black Americans. This reflects the paucity of clinical SCD pain research and limited understanding of the complex biological differences between acute and chronic pain.