of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.
,A UniProt proteome can consist of several components.
The component name refers to the genomic component encoding a set of proteins.
This section provides information on the location and the topology of the mature protein in the cell.
,This subsection of the 'Subcellular location' section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.
,This subsection of the 'Subcellular location' section describes the extent of a membrane-spanning region of the protein. of multiple genes (paralogs).
Alpha-1D adrenoreceptor. The majority of alpha-1 receptors are directed toward the function of epinephrine, a hormone that has to do with the fight-or-flight response. They activate mitogenic responses and regulate growth and proliferation of many cells. Alternative name(s): Alpha-1A adrenergic receptor. There is no α1C receptor. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. Alpha-1D adrenergic receptor. T.P.More information in the GO evidence code guide
,Inferred from Biological aspect of Ancestor
Alpha-receptors are located on the arteries. Different subtypes show different patterns of activation.Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.
The version number for both the entry and the canonical sequence are also displayed.,This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).
, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation. have the same checksum value, the likelihood that this would happen We'd like to inform you that we have updated our Privacy Notice to comply The 5-HT 1D(Gi/Go) Receptor. Meanwhile, a beta receptor (beta-adrenergic receptor) is any group of adrenergic receptors found on the cell surface of tissues and effector organs.More information in the GO evidence code guide
, Inferred from biological aspect of ancestor,Inferred from Mutant Phenotype
RNAct, Protein-RNA interaction predictions for model organisms. ,When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.
,This indicates the type of evidence that supports the existence of the protein. (1991) concluded that the gene for what they called alpha-1A receptor is located on chromosome 5 in the region q23-q32, the same region thought to contain the ADRA1B gene and the ADRB2 gene ().The close proximity of 3 adrenergic receptors on the same chromosome suggested that this family of proteins arose by gene duplication. Choose from 500 different sets of adrenergic receptor locations flashcards on Quizlet.
Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. 36:370-379(2016). Manual assertion inferred from sequence similarity toi, BindingDB database of measured binding affinities. J. Physiol. It also includes information pertinent to the sequence(s), including length and molecular weight.
This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
Sequence statusi: Complete. Alpha-adrenergic receptor 1a ... Subcellular location i.This subsection of the Names and taxonomy section indicates the name (s) of the gene (s) that code for the protein sequence (s) described in the entry. Location & Maps more. Short name: ... Subcellular location i. of multiple genes (paralogs).
from the sequence. Cyclic redundancy and other checksumsMore information in the GO evidence code guide
,Inferred from Genetic Interaction
An alpha receptor (alpha-adrenergic receptor) is a type of adrenergic receptor that triggers physiological responses such as smooth muscle contraction, vasoconstriction, pupil dilation, and intestinal muscle relaxation.. They activate mitogenic responses and regulate growth and proliferation of many cells. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins., Automatic assertion according to sequence analysis,This section provides information on the disease(s) and phenotype(s) associated with a protein.
,This section describes post-translational modifications (PTMs) and/or processing events.
,This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.
,This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.
,This subsection of the 'Interaction' section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the 'Function' section).
,This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.
,This subsection of the Family and Domains section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.
,Information which has been generated by the UniProtKB automatic annotation system, without manual validation.